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Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells

The alteration of amyloid precursor protein (APP) proteolysis is a hallmark of Alzheimer's disease (AD). Recent studies have described noncanonical pathways of APP processing that seem partly executed by lysosomal enzymes. Our laboratory's in vitro human SK-N-MC model has shown that oxidat...

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Detalles Bibliográficos
Autores principales:	Llorente, Patricia, Martins, Soraia, Sastre, Isabel, Aldudo, Jesús, Recuero, María, Adjaye, James, Bullido, Maria J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685830/ https://www.ncbi.nlm.nih.gov/pubmed/33282112 http://dx.doi.org/10.1155/2020/5917187

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