Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra

Chronic consumption of β-sitosterol-β-D-glucoside (BSSG), a neurotoxin contained in cycad seeds, leads to Parkinson's disease in humans and rodents. Here, we explored whether a single intranigral administration of BSSG triggers neuroinflammation and neurotoxic A1 reactive astrocytes besides dop...

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Detalles Bibliográficos
Autores principales: Luna-Herrera, Claudia, Martínez-Dávila, Irma A., Soto-Rojas, Luis O., Flores-Martinez, Yazmin M., Fernandez-Parrilla, Manuel A., Ayala-Davila, Jose, León-Chavez, Bertha A., Soto-Rodriguez, Guadalupe, Blanco-Alvarez, Victor M., Lopez-Salas, Francisco E., Gutierrez-Castillo, Maria E., Gatica-Garcia, Bismark, Padilla-Viveros, America, Bañuelos, Cecilia, Reyes-Corona, David, Espadas-Alvarez, Armando J., Garcés-Ramírez, Linda, Hidalgo-Alegria, Oriana, De La Cruz-lópez, Fidel, Martinez-Fong, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685831/
https://www.ncbi.nlm.nih.gov/pubmed/33282962
http://dx.doi.org/10.1155/2020/5907591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685831/
https://www.ncbi.nlm.nih.gov/pubmed/33282962
http://dx.doi.org/10.1155/2020/5907591

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