Overcoming the blood–brain barrier by Annexin A1-binding peptide to target brain tumours

BACKGROUND: Annexin A1 is expressed specifically on the tumour vasculature surface. Intravenously injected IF7 targets tumour vasculature via annexin A1. We tested the hypothesis that IF7 overcomes the blood–brain barrier and that the intravenously injected IF7C(RR)-SN38 eradicates brain tumours in...

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Detalles Bibliográficos
Autores principales: Nonaka, Motohiro, Suzuki-Anekoji, Misa, Nakayama, Jun, Mabashi-Asazuma, Hideaki, Jarvis, Donald L., Yeh, Jiunn-Chern, Yamasaki, Kazuhiko, Akama, Tomoya O., Huang, Chun-Teng, Campos, Alexandre Rosa, Nagaoka, Masato, Sasai, Toshio, Kimura-Takagi, Itsuko, Suwa, Yoichi, Yaegashi, Takashi, Shibata, Toshiaki K., Sugihara, Kazuhiro, Nishizawa-Harada, Chizuko, Fukuda, Minoru, Fukuda, Michiko N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686308/
https://www.ncbi.nlm.nih.gov/pubmed/32921792
http://dx.doi.org/10.1038/s41416-020-01066-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686308/
https://www.ncbi.nlm.nih.gov/pubmed/32921792
http://dx.doi.org/10.1038/s41416-020-01066-2

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