α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice

Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark. Although the major aggregating peptide in β-cells of T2D patients is Islet Amyloid Polypeptide (IAPP), alpha-synuclein (αSyn...

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Detalles Bibliográficos
Autores principales: Mucibabic, Marija, Steneberg, Pär, Lidh, Emmelie, Straseviciene, Jurate, Ziolkowska, Agnieszka, Dahl, Ulf, Lindahl, Emma, Edlund, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686322/
https://www.ncbi.nlm.nih.gov/pubmed/33235246
http://dx.doi.org/10.1038/s41598-020-77409-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686322/
https://www.ncbi.nlm.nih.gov/pubmed/33235246
http://dx.doi.org/10.1038/s41598-020-77409-z

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