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Complex fibroblast response to glucocorticoids may underlie variability of clinical efficacy in the vocal folds

Similar to the hypertrophic scar and keloids, the efficacy of glucorticoids (GC) for vocal fold injury is highly variable. We previously reported dexamethasone enhanced the pro-fibrotic effects of transforming growth factor (TGF)-β as a potential mechanism for inconsistent clinical outcomes. In the...

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Detalles Bibliográficos
Autores principales: Nakamura, Ryosuke, Mukudai, Shigeyuki, Bing, Renjie, Garabedian, Michael J., Branski, Ryan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686477/
https://www.ncbi.nlm.nih.gov/pubmed/33235235
http://dx.doi.org/10.1038/s41598-020-77445-9