Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

Convergent data from imaging and postmortem brain transcriptome studies implicate corticolimbic circuit (CLC) dysregulation in the pathophysiology of depression. To more directly bridge these lines of work, we generated a novel transcriptome-based polygenic risk score (T-PRS), capturing subtle shift...

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Detalles Bibliográficos
Autores principales: Mareckova, Klara, Hawco, Colin, Dos Santos, Fernanda C., Bakht, Arin, Calarco, Navona, Miles, Amy E., Voineskos, Aristotle N., Sibille, Etienne, Hariri, Ahmad R., Nikolova, Yuliya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686479/
https://www.ncbi.nlm.nih.gov/pubmed/33235204
http://dx.doi.org/10.1038/s41398-020-01093-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686479/
https://www.ncbi.nlm.nih.gov/pubmed/33235204
http://dx.doi.org/10.1038/s41398-020-01093-w

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