Selective Modulation of α5 GABA(A) Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease

Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABA(A) receptors (GABA(A)Rs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer’s disease (AD), continually fail clinical trials. We investigated whether this was due...

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Detalles Bibliográficos
Autores principales: Petrache, Alexandra L., Khan, Archie A., Nicholson, Martin W., Monaco, Alessandra, Kuta-Siejkowska, Martyna, Haider, Shozeb, Hilton, Stephen, Jovanovic, Jasmina N., Ali, Afia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686552/
https://www.ncbi.nlm.nih.gov/pubmed/33262690
http://dx.doi.org/10.3389/fncel.2020.568194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686552/
https://www.ncbi.nlm.nih.gov/pubmed/33262690
http://dx.doi.org/10.3389/fncel.2020.568194

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