Cargando…

Selective Modulation of α5 GABA(A) Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease

Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABA(A) receptors (GABA(A)Rs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer’s disease (AD), continually fail clinical trials. We investigated whether this was due...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petrache, Alexandra L., Khan, Archie A., Nicholson, Martin W., Monaco, Alessandra, Kuta-Siejkowska, Martyna, Haider, Shozeb, Hilton, Stephen, Jovanovic, Jasmina N., Ali, Afia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686552/ https://www.ncbi.nlm.nih.gov/pubmed/33262690 http://dx.doi.org/10.3389/fncel.2020.568194

Ejemplares similares

Carbazole Derivatives’ Binding to c-KIT G-Quadruplex DNA
por: Głuszyńska, Agata, et al.
Publicado: (2018)

Preserved Calretinin Interneurons in an App Model of Alzheimer’s Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors
por: Shi, Anqi, et al.
Publicado: (2020)

Control of cell surface expression of GABA(A) receptors by a conserved region at the end of the N-terminal extracellular domain of receptor subunits
por: Yuan, Banghao, et al.
Publicado: (2022)

The blood-to-plasma ratio and predicted GABA(A)-binding affinity of designer benzodiazepines
por: Manchester, Kieran R., et al.
Publicado: (2022)

GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model
por: Liu, Junxiu, et al.
Publicado: (2019)

Hypothalamic Glutamate/GABA Cotransmission Modulates Hippocampal Circuits and Supports Long-Term Potentiation
por: Ajibola, Musa Iyiola, et al.
Publicado: (2021)

Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit
por: Salmon, Christopher K., et al.
Publicado: (2020)

Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia
por: Kätzel, Dennis, et al.
Publicado: (2020)

GABA release by hippocampal astrocytes
por: Le Meur, Karim, et al.
Publicado: (2012)

Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model
por: Aldabbagh, Yousif, et al.
Publicado: (2022)

Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease
por: Petrache, Alexandra L, et al.
Publicado: (2019)

Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits
por: Chen, Liying, et al.
Publicado: (2023)

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABA(A) Receptors
por: Brown, Laura E., et al.
Publicado: (2014)

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca(2+)/calcineurin signalling downstream of GABAA receptors
por: Nicholson, Martin W., et al.
Publicado: (2018)

γ-Aminobutyric Acid Type A (GABA(A)) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains
por: Brown, Laura E., et al.
Publicado: (2016)

Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model
por: Khan, Archie A, et al.
Publicado: (2018)

Co-transmission of acetylcholine and GABA regulates hippocampal states
por: Takács, Virág T., et al.
Publicado: (2018)

Hippocampal circuit dysfunction in psychosis
por: Knight, Samuel, et al.
Publicado: (2022)

Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome
por: Gao, Fei, et al.
Publicado: (2018)

Extracellular GABA waves regulate coincidence detection in excitatory circuits
por: Sylantyev, Sergiy, et al.
Publicado: (2020)

GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons
por: Golan, H., et al.
Publicado: (2000)

Hippocampal GABA enables inhibitory control over unwanted thoughts
por: Schmitz, Taylor W., et al.
Publicado: (2017)

Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
por: Modinos, Gemma, et al.
Publicado: (2018)

Significance of GABA(A) Receptor for Cognitive Function and Hippocampal Pathology
por: Sakimoto, Yuya, et al.
Publicado: (2021)

The fate of interneurons, GABA(A) receptor sub‐types and perineuronal nets in Alzheimer's disease
por: Ali, Afia B., et al.
Publicado: (2022)

Reorganization of spatial maps in the hippocampal circuit
por: Stella, Federico, et al.
Publicado: (2011)

A Handbook for Modeling Hippocampal Circuits
por: Hasselmo, Michael E.
Publicado: (2011)

Correction: Hippocampal circuit dysfunction in psychosis
por: Knight, Samuel, et al.
Publicado: (2022)

Activation of GABA(A) Receptors in Colon Epithelium Exacerbates Acute Colitis
por: Ma, Xuelian, et al.
Publicado: (2018)

GABA(A) receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons
por: Arama, Jessica, et al.
Publicado: (2015)

GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses
por: Fuchs, Celine, et al.
Publicado: (2013)

Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease
por: Zhou, Heng, et al.
Publicado: (2022)

Celsr3 Is Required for Normal Development of GABA Circuits in the Inner Retina
por: Lewis, Alaron, et al.
Publicado: (2011)

GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
por: Gonzalez-Burgos, Guillermo, et al.
Publicado: (2011)

Emerging neurotrophic role of GABA(B) receptors in neuronal circuit development
por: Gaiarsa, Jean-Luc, et al.
Publicado: (2013)

Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
por: Song, Inseon, et al.
Publicado: (2011)

A role for GABA in the modulation of striatal and hippocampal systems under stress
por: Dolfen, Nina, et al.
Publicado: (2021)

Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network
por: Magloire, Vincent, et al.
Publicado: (2023)

Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP
por: Tambini, Marc D., et al.
Publicado: (2019)

Increased Voluntary Alcohol Consumption in Mice Lacking GABA(B(1)) Is Associated With Functional Changes in Hippocampal GABA(A) Receptors
por: Floris, Gabriele, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4gckc9jjhf9lkolpti6g7eg5c3