Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming

BACKGROUND: Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated lipid accumulation per cell in vitro. The present study examines chromatin access...

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Detalles Bibliográficos
Autores principales: Leung, Karen L., Sanchita, Smriti, Pham, Catherine T., Davis, Brett A., Okhovat, Mariam, Ding, Xiangming, Dumesic, Phillip, Grogan, Tristan R., Williams, Kevin J., Morselli, Marco, Ma, Feiyang, Carbone, Lucia, Li, Xinmin, Pellegrini, Matteo, Dumesic, Daniel A., Chazenbalk, Gregorio D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686698/
https://www.ncbi.nlm.nih.gov/pubmed/33228780
http://dx.doi.org/10.1186/s13148-020-00970-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686698/
https://www.ncbi.nlm.nih.gov/pubmed/33228780
http://dx.doi.org/10.1186/s13148-020-00970-x

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