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circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. However, the function and mechanism of circRNA in autophagy regulation of LSCC remain...

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Detalles Bibliográficos
Autores principales: Gao, Wei, Guo, Huina, Niu, Min, Zheng, Xiwang, Zhang, Yuliang, Xue, Xuting, Bo, Yunfeng, Guan, Xiaoya, Li, Zhongxun, Guo, Yujia, He, Long, Zhang, Yu, Li, Li, Cao, Jimin, Wu, Yongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686732/
https://www.ncbi.nlm.nih.gov/pubmed/33234130
http://dx.doi.org/10.1186/s12943-020-01279-2