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Loop Grafting between Similar Local Environments for Fc-Silent Antibodies

[Image: see text] Reduction of the affinity of the fragment crystallizable (Fc) region with immune receptors by substitution of one or a few amino acids, known as Fc-silencing, is an established approach to reduce the immune effector functions of monoclonal antibody therapeutics. This approach to Fc...

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Detalles Bibliográficos
Autores principales: Lešnik, Samo, Hodošček, Milan, Podobnik, Barbara, Konc, Janez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686954/
https://www.ncbi.nlm.nih.gov/pubmed/32379970
http://dx.doi.org/10.1021/acs.jcim.9b01198