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Loop Grafting between Similar Local Environments for Fc-Silent Antibodies
[Image: see text] Reduction of the affinity of the fragment crystallizable (Fc) region with immune receptors by substitution of one or a few amino acids, known as Fc-silencing, is an established approach to reduce the immune effector functions of monoclonal antibody therapeutics. This approach to Fc...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686954/ https://www.ncbi.nlm.nih.gov/pubmed/32379970 http://dx.doi.org/10.1021/acs.jcim.9b01198 |