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Thrombospondin‐2 stimulates MMP‐9 production and promotes osteosarcoma metastasis via the PLC, PKC, c‐Src and NF‐κB activation
Osteosarcoma is an extremely common primary bone malignancy that is highly metastatic, with most deaths resulting from pulmonary metastases. The extracellular matrix protein thrombospondin‐2 (TSP‐2) is key to many biological processes, such as inflammation, wound repair and tissue remodelling. Howev...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686970/ https://www.ncbi.nlm.nih.gov/pubmed/33021341 http://dx.doi.org/10.1111/jcmm.15874 |