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Thrombospondin‐2 stimulates MMP‐9 production and promotes osteosarcoma metastasis via the PLC, PKC, c‐Src and NF‐κB activation

Osteosarcoma is an extremely common primary bone malignancy that is highly metastatic, with most deaths resulting from pulmonary metastases. The extracellular matrix protein thrombospondin‐2 (TSP‐2) is key to many biological processes, such as inflammation, wound repair and tissue remodelling. Howev...

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Detalles Bibliográficos
Autores principales:	Liu, Ju‐Fang, Chen, Po‐Chun, Chang, Tsung‐Ming, Hou, Chun‐Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686970/ https://www.ncbi.nlm.nih.gov/pubmed/33021341 http://dx.doi.org/10.1111/jcmm.15874

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