Fragments as Novel Starting Points for tRNA‐Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies

Crystallography provides structural information crucial for fragment optimization, however several criteria must be met to screen directly on protein crystals as soakable, well‐diffracting specimen must be available. We screened a 96‐fragment library against the tRNA‐modifying enzyme TGT using cryst...

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Detalles Bibliográficos
Autores principales: Hassaan, Engi, Eriksson, Per‐Olof, Geschwindner, Stefan, Heine, Andreas, Klebe, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687107/
https://www.ncbi.nlm.nih.gov/pubmed/31808981
http://dx.doi.org/10.1002/cmdc.201900604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687107/
https://www.ncbi.nlm.nih.gov/pubmed/31808981
http://dx.doi.org/10.1002/cmdc.201900604

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