Cargando…
Fragments as Novel Starting Points for tRNA‐Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies
Crystallography provides structural information crucial for fragment optimization, however several criteria must be met to screen directly on protein crystals as soakable, well‐diffracting specimen must be available. We screened a 96‐fragment library against the tRNA‐modifying enzyme TGT using cryst...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687107/ https://www.ncbi.nlm.nih.gov/pubmed/31808981 http://dx.doi.org/10.1002/cmdc.201900604 |