Target‐Directed Azide‐Alkyne Cycloaddition for Assembling HIV‐1 TAR RNA Binding Ligands

The highly conserved HIV‐1 transactivation response element (TAR) binds to the trans‐activator protein Tat and facilitates viral replication in its latent state. The inhibition of Tat–TAR interactions by selectively targeting TAR RNA has been used as a strategy to develop potent antiviral agents. Th...

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Detalles Bibliográficos
Autores principales: Paul, Rakesh, Dutta, Debasish, Paul, Raj, Dash, Jyotirmayee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687225/
https://www.ncbi.nlm.nih.gov/pubmed/32329147
http://dx.doi.org/10.1002/anie.202003461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687225/
https://www.ncbi.nlm.nih.gov/pubmed/32329147
http://dx.doi.org/10.1002/anie.202003461

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