A Single‐Dose, Open‐Label, Randomized, Two‐Way Crossover Study in Healthy Japanese Participants to Evaluate the Bioequivalence and the Food Effect on the Pharmacokinetics of Daprodustat

Daprodustat is a prolyl hydroxylase inhibitor that stimulates erythropoiesis in a manner similar to the natural response to hypoxia, whereby inhibition of hypoxia inducible factor (HIF) prolyl‐4‐hydroxylases by daprodustat ultimately results in increased levels of HIF‐responsive genes. Daprodustat i...

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Detalles Bibliográficos
Autores principales: Yamada, Masanori, Osamura, Minori, Ogura, Hirofumi, Onoue, Tomohiro, Wakamatsu, Akira, Numachi, Yotaro, Caltabiano, Stephen, Mahar, Kelly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687240/
https://www.ncbi.nlm.nih.gov/pubmed/32250021
http://dx.doi.org/10.1002/cpdd.793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687240/
https://www.ncbi.nlm.nih.gov/pubmed/32250021
http://dx.doi.org/10.1002/cpdd.793

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