Conserved epitopes with high HLA-I population coverage are targets of CD8(+) T cells associated with high IFN-γ responses against all dengue virus serotypes

Cytotoxic CD8(+) T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses and their cross-reactivity against multiple...

Descripción completa

Detalles Bibliográficos
Autores principales: Adikari, Thiruni N., Di Giallonardo, Francesca, Leung, Preston, Grifoni, Alba, Sette, Alex, Weiskopf, Daniela, Bull, Rowena A., Luciani, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687909/
https://www.ncbi.nlm.nih.gov/pubmed/33235334
http://dx.doi.org/10.1038/s41598-020-77565-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687909/
https://www.ncbi.nlm.nih.gov/pubmed/33235334
http://dx.doi.org/10.1038/s41598-020-77565-2

Ejemplares similares