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Conserved epitopes with high HLA-I population coverage are targets of CD8(+) T cells associated with high IFN-γ responses against all dengue virus serotypes

Cytotoxic CD8(+) T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses and their cross-reactivity against multiple...

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Detalles Bibliográficos
Autores principales:	Adikari, Thiruni N., Di Giallonardo, Francesca, Leung, Preston, Grifoni, Alba, Sette, Alex, Weiskopf, Daniela, Bull, Rowena A., Luciani, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687909/ https://www.ncbi.nlm.nih.gov/pubmed/33235334 http://dx.doi.org/10.1038/s41598-020-77565-2

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