Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response

BACKGROUND: Chemoresistance remains a major treatment obstacle in multiple myeloma (MM). Novel new therapies are thus in need. Transient Receptor Potential Vanilloid type 1 (TRPV1) is a calcium-permeable ion channel that has been demonstrated to be expressed in solid tumors. Calcium channels have be...

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Detalles Bibliográficos
Autores principales: Beider, Katia, Rosenberg, Evgenia, Dimenshtein-Voevoda, Valeria, Sirovsky, Yaarit, Vladimirsky, Julia, Magen, Hila, Ostrovsky, Olga, Shimoni, Avichai, Bromberg, Zohar, Weiss, Lola, Peled, Amnon, Nagler, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687998/
https://www.ncbi.nlm.nih.gov/pubmed/33239060
http://dx.doi.org/10.1186/s13045-020-00993-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687998/
https://www.ncbi.nlm.nih.gov/pubmed/33239060
http://dx.doi.org/10.1186/s13045-020-00993-0

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