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Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response

BACKGROUND: Chemoresistance remains a major treatment obstacle in multiple myeloma (MM). Novel new therapies are thus in need. Transient Receptor Potential Vanilloid type 1 (TRPV1) is a calcium-permeable ion channel that has been demonstrated to be expressed in solid tumors. Calcium channels have be...

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Detalles Bibliográficos
Autores principales:	Beider, Katia, Rosenberg, Evgenia, Dimenshtein-Voevoda, Valeria, Sirovsky, Yaarit, Vladimirsky, Julia, Magen, Hila, Ostrovsky, Olga, Shimoni, Avichai, Bromberg, Zohar, Weiss, Lola, Peled, Amnon, Nagler, Arnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687998/ https://www.ncbi.nlm.nih.gov/pubmed/33239060 http://dx.doi.org/10.1186/s13045-020-00993-0

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