Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

DNA viruses in the family Poxviridae encode poxin enzymes that degrade the immune second messenger 2′3′-cGAMP to inhibit cGAS-STING immunity in mammalian cells. The closest homologs of poxin exist in the genomes of insect viruses suggesting a key mechanism of cGAS-STING evasion may have evolved outs...

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Detalles Bibliográficos
Autores principales: Eaglesham, James B, McCarty, Kacie L, Kranzusch, Philip J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688311/
https://www.ncbi.nlm.nih.gov/pubmed/33191912
http://dx.doi.org/10.7554/eLife.59753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688311/
https://www.ncbi.nlm.nih.gov/pubmed/33191912
http://dx.doi.org/10.7554/eLife.59753

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