GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family of cytokines, maintains Ewing sarcoma growth by preventing Src hyperactivation. Surprisingly, Ewing sarcoma depends on the prodomain, not the BM...

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Detalles Bibliográficos
Autores principales: Zhou, Fuchun, Elzi, David J., Jayabal, Panneerselvam, Ma, Xiuye, Chiu, Yu-Chiao, Chen, Yidong, Blackman, Barron, Weintraub, Susan T., Houghton, Peter J., Shiio, Yuzuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688343/
https://www.ncbi.nlm.nih.gov/pubmed/33147457
http://dx.doi.org/10.1016/j.celrep.2020.108332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688343/
https://www.ncbi.nlm.nih.gov/pubmed/33147457
http://dx.doi.org/10.1016/j.celrep.2020.108332

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