D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics

The transition of antimicrobial peptides (AMPs) from the laboratory to market has been severely hindered by their instability toward proteases in biological systems. In the present study, we synthesized derivatives of the cationic AMP Pep05 (KRLFKKLLKYLRKF) by substituting L-amino acid residues with...

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Detalles Bibliográficos
Autores principales: Lu, Jianguang, Xu, Hongjiang, Xia, Jianghua, Ma, Jie, Xu, Jun, Li, Yanan, Feng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688903/
https://www.ncbi.nlm.nih.gov/pubmed/33281761
http://dx.doi.org/10.3389/fmicb.2020.563030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688903/
https://www.ncbi.nlm.nih.gov/pubmed/33281761
http://dx.doi.org/10.3389/fmicb.2020.563030

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