Longitudinal Characterization of Transcriptomic, Functional, and Morphological Features in Human iPSC-Derived Neurons and Their Application to Investigate Translational Progranulin Disease Biology

The disease biology of frontotemporal lobe dementia (FTD) is complex and not fully understood, with limited translational value appreciated from animal models to date. Human cellular systems that can recapitulate phenotypic features of disease offer promise as translational tools to not only increas...

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Detalles Bibliográficos
Autores principales: Robin, Gaëlle, Evans, J. Corey, Hauser, David N., Wren, Paul, Zembrzycki, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689020/
https://www.ncbi.nlm.nih.gov/pubmed/33281596
http://dx.doi.org/10.3389/fnagi.2020.576678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689020/
https://www.ncbi.nlm.nih.gov/pubmed/33281596
http://dx.doi.org/10.3389/fnagi.2020.576678

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