Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclization to develop a peptidomimetic painkiller. Backbo...

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Detalles Bibliográficos
Autores principales: Talhami, Alaa, Swed, Avi, Hess, Shmuel, Ovadia, Oded, Greenberg, Sarit, Schumacher-Klinger, Adi, Rosenthal, David, Shalev, Deborah E., Hurevich, Mattan, Lazarovici, Philip, Hoffman, Amnon, Gilon, Chaim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689096/
https://www.ncbi.nlm.nih.gov/pubmed/33282822
http://dx.doi.org/10.3389/fchem.2020.532577