Cargando…

Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclization to develop a peptidomimetic painkiller. Backbo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Talhami, Alaa, Swed, Avi, Hess, Shmuel, Ovadia, Oded, Greenberg, Sarit, Schumacher-Klinger, Adi, Rosenthal, David, Shalev, Deborah E., Hurevich, Mattan, Lazarovici, Philip, Hoffman, Amnon, Gilon, Chaim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689096/ https://www.ncbi.nlm.nih.gov/pubmed/33282822 http://dx.doi.org/10.3389/fchem.2020.532577

Ejemplares similares

A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids
por: Samarasimhareddy, Mamidi, et al.
Publicado: (2020)

Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88
por: Dishon, Shira, et al.
Publicado: (2018)

Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis
por: Gilon, Chaim, et al.
Publicado: (2021)

DMAP-assisted sulfonylation as an efficient step for the methylation of primary amine motifs on solid support
por: Naoum, Johnny N, et al.
Publicado: (2017)

Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions
por: Tadi, Kiran Kumar, et al.
Publicado: (2017)

Over-the-Counter Painkillers and Evolutionary Mismatch
por: Gallup, Andrew C.
Publicado: (2019)

Enhancing Robustness of Sortase A by Loop Engineering and Backbone Cyclization
por: Zou, Zhi, et al.
Publicado: (2020)

Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain
por: Schumann, Frank H., et al.
Publicado: (2015)

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
por: Harris, Karen S., et al.
Publicado: (2015)

Potentiometric Sensing of Nonsteroidal Painkillers by Acyclic Squaramide Ionophores
por: Picci, Giacomo, et al.
Publicado: (2023)

Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives
por: Yoo, Sungjae, et al.
Publicado: (2013)

Structure‐based drug discovery facilitates future painkiller development
por: Li, Yuqing, et al.
Publicado: (2022)

Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models
por: Ye, Bingyu, et al.
Publicado: (2018)

Screen-Printed Voltammetric Sensors—Tools for Environmental Water Monitoring of Painkillers
por: Tyszczuk-Rotko, Katarzyna, et al.
Publicado: (2022)

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
por: Gunasekera, Sunithi, et al.
Publicado: (2020)

N-Terminal cysteine mediated backbone-side chain cyclization for chemically enhanced phage display
por: Zheng, Mengmeng, et al.
Publicado: (2022)

The effects of injections of warmed bicarbonate-buffered Lidocaine as a painkiller for patients with trauma
por: Azizkhani, Reza, et al.
Publicado: (2015)

A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine
por: Feng, Jiao, et al.
Publicado: (2019)

Utilization of Over-the-Counter Painkillers Among Medical Students During Academic Examinations
por: Rajab, Mohammad H, et al.
Publicado: (2023)

Prescription painkillers and controlled substances: an appraisal of drug information provided by six US pharmacies
por: Gill, Preetinder S
Publicado: (2013)

Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis
por: Qi, Xingmei, et al.
Publicado: (2017)

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design
por: Reinwarth, Michael, et al.
Publicado: (2012)

Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages
por: Hahm, Heung Sik, et al.
Publicado: (2016)

The prevalence of musculoskeletal pain and use of painkillers among adolescent male ice hockey players in Finland
por: Selanne, Harri, et al.
Publicado: (2014)

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region, Italy
por: Scuteri, Damiana, et al.
Publicado: (2018)

Hazards and risk assessment of heavy metals from consumption of locally manufactured painkiller drugs in Nigeria
por: Nduka, John Kanayochukwu, et al.
Publicado: (2020)

The effect of radiofrequency ablation on pain score and non-steroidal painkiller use in osteoid osteoma patients
por: Mahmutoğlu, Abdullah Soydan, et al.
Publicado: (2023)

A pill as a quick solution: association between painkiller intake, empathy, and prosocial behavior
por: Banwinkler, Magdalena, et al.
Publicado: (2023)

Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs
por: Darnaud, Léa, et al.
Publicado: (2023)

Impedimetric Bacterial Detection Using Random Antimicrobial Peptide Mixtures
por: Stern Bauer, Tal, et al.
Publicado: (2023)

Factors Affecting Painkillers, Sedatives/Hypnotics, Nicotine, and Unhealthy Alcohol Use Among Gay and Bisexual Men in Taiwan
por: Li, Dian-Jeng, et al.
Publicado: (2020)

Automated synthesis of sialylated oligosaccharides
por: Esposito, Davide, et al.
Publicado: (2012)

The molecular basis of memory. Part 3: tagging with “emotive” neurotransmitters
por: Marx, Gerard, et al.
Publicado: (2014)

Accelerated Multiphosphorylated Peptide Synthesis
por: Grunhaus, Dana, et al.
Publicado: (2022)

Unexpected Nucleophile Masking in Acyl Transfer to Sterically Crowded and Conformationally Restricted Galactosides
por: Sukhran, Yonatan, et al.
Publicado: (2023)

backbone: An R package to extract network backbones
por: Neal, Zachary P.
Publicado: (2022)

Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization
por: Orlov, Dmitriy S., et al.
Publicado: (2019)

Status of hormones and painkillers in wastewater effluents across several European states—considerations for the EU watch list concerning estradiols and diclofenac
por: Schröder, P., et al.
Publicado: (2016)

Interrelationships between migraine over the counter (OTC) painkillers and hypertensive disorders of pregnancy: A protocol for systematic review and meta-analysis
por: Nkuna, Shalati L., et al.
Publicado: (2021)

Backbone: An R package for extracting the backbone of bipartite projections
por: Domagalski, Rachel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k71otujtp4mjibk1is9bgkbh01