Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Genome-wide association studies have reported that, amongst other microglial genes, variants in TREM2 can profoundly increase the incidence of developing Alzheimer’s disease (AD). We have investigated the role of TREM2 in primary microglial cultures from wild type mice by using siRNA to decrease Tre...

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Detalles Bibliográficos
Autores principales: Liu, Wenfei, Taso, Orjona, Wang, Rui, Bayram, Sevinc, Graham, Andrew C, Garcia-Reitboeck, Pablo, Mallach, Anna, Andrews, William D, Piers, Thomas M, Botia, Juan A, Pocock, Jennifer M, Cummings, Damian M, Hardy, John, Edwards, Frances A, Salih, Dervis A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689298/
https://www.ncbi.nlm.nih.gov/pubmed/32959884
http://dx.doi.org/10.1093/hmg/ddaa209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689298/
https://www.ncbi.nlm.nih.gov/pubmed/32959884
http://dx.doi.org/10.1093/hmg/ddaa209

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