De novo post-SELEX optimization of a G-quadruplex DNA aptamer binding to marine toxin gonyautoxin 1/4

Ligand-binding aptamers obtained by SELEX (Systematic Evolution of Ligands by EXponential enrichment) often have low affinity or/and specificity, and post-SELEX optimization is usually needed. Due to experimental difficulty in determining three-dimensional (3D) structures of aptamer-ligand complexes...

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Detalles Bibliográficos
Autores principales: Song, Menghua, Li, Gan, Zhang, Qi, Liu, Jianping, Huang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689369/
https://www.ncbi.nlm.nih.gov/pubmed/33294137
http://dx.doi.org/10.1016/j.csbj.2020.10.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689369/
https://www.ncbi.nlm.nih.gov/pubmed/33294137
http://dx.doi.org/10.1016/j.csbj.2020.10.041

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