Structural basis for inhibition of an archaeal CRISPR–Cas type I-D large subunit by an anti-CRISPR protein

A hallmark of type I CRISPR–Cas systems is the presence of Cas3, which contains both the nuclease and helicase activities required for DNA cleavage during interference. In subtype I-D systems, however, the histidine-aspartate (HD) nuclease domain is encoded as part of a Cas10-like large effector com...

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Detalles Bibliográficos
Autores principales: Manav, M. Cemre, Van, Lan B., Lin, Jinzhong, Fuglsang, Anders, Peng, Xu, Brodersen, Ditlev E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689449/
https://www.ncbi.nlm.nih.gov/pubmed/33239638
http://dx.doi.org/10.1038/s41467-020-19847-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689449/
https://www.ncbi.nlm.nih.gov/pubmed/33239638
http://dx.doi.org/10.1038/s41467-020-19847-x

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