Proof of Concept: First Pediatric [(14)C]microtracer Study to Create Metabolite Profiles of Midazolam

Growth and development affect drug‐metabolizing enzyme activity thus could alter the metabolic profile of a drug. Traditional studies to create metabolite profiles and study the routes of excretion are unethical in children due to the high radioactive burden. To overcome this challenge, we aimed to...

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Detalles Bibliográficos
Autores principales: van Groen, Bianca D., van Duijn, Esther, de Vries, Arjan, Mooij, Miriam G., Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689753/
https://www.ncbi.nlm.nih.gov/pubmed/32386327
http://dx.doi.org/10.1002/cpt.1884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689753/
https://www.ncbi.nlm.nih.gov/pubmed/32386327
http://dx.doi.org/10.1002/cpt.1884

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