Cargando…

Proof of Concept: First Pediatric [(14)C]microtracer Study to Create Metabolite Profiles of Midazolam

Growth and development affect drug‐metabolizing enzyme activity thus could alter the metabolic profile of a drug. Traditional studies to create metabolite profiles and study the routes of excretion are unethical in children due to the high radioactive burden. To overcome this challenge, we aimed to...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Groen, Bianca D., van Duijn, Esther, de Vries, Arjan, Mooij, Miriam G., Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689753/ https://www.ncbi.nlm.nih.gov/pubmed/32386327 http://dx.doi.org/10.1002/cpt.1884

Ejemplares similares

The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study
por: van Groen, Bianca D., et al.
Publicado: (2020)

Dose‐linearity of the pharmacokinetics of an intravenous [(14)C]midazolam microdose in children
por: van Groen, Bianca D., et al.
Publicado: (2019)

Pediatric Microdose Study of [(14)C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
por: Mooij, Miriam G., et al.
Publicado: (2014)

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a (26)Al Microtracer Approach
por: de Ligt, Rianne, et al.
Publicado: (2018)

Innovative approaches and recent advances in the study of ontogeny of drug metabolism and transport
por: van Groen, Bianca D., et al.
Publicado: (2020)

Successful Use of [(14)C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism
por: Mooij, Miriam G., et al.
Publicado: (2017)

Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver
por: van Groen, Bianca D., et al.
Publicado: (2020)

A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept
por: Hartman, Stan J. F., et al.
Publicado: (2020)

Ontogeny of midazolam glucuronidation in preterm infants
por: de Wildt, Saskia N., et al.
Publicado: (2009)

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics
por: Mooij, Miriam G., et al.
Publicado: (2015)

Opportunities in low-level radiocarbon microtracing: applications and new technology
por: Vuong, Le Thuy, et al.
Publicado: (2015)

Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure
por: Brussee, Janneke M., et al.
Publicado: (2017)

Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a ((26)Al)Al microtracer approach: a follow-up study in humans
por: de Ligt, Rianne, et al.
Publicado: (2022)

Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial
por: Bestebreurtje, Petra, et al.
Publicado: (2020)

Daily interruption of sedation in critically ill children: study protocol for a randomized controlled trial
por: Vet, Nienke J, et al.
Publicado: (2014)

Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients
por: Franken, Linda G., et al.
Publicado: (2017)

A randomized controlled trial of daily sedation interruption in critically ill children
por: Vet, Nienke J., et al.
Publicado: (2015)

Oral lorazepam can be substituted for intravenous midazolam when weaning paediatric intensive care patients off sedation
por: van der Vossen, Anna C., et al.
Publicado: (2018)

Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery
por: Zeilmaker-Roest, Gerda A., et al.
Publicado: (2018)

Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a (14)C-microtracer and therapeutic dose in cancer patients
por: van Andel, L., et al.
Publicado: (2017)

Clinical Pharmacokinetics of Daprodustat: Results of an Absorption, Distribution, and Excretion Study With Intravenous Microtracer and Concomitant Oral Doses for Bioavailability Determination
por: Mahar, Kelly M., et al.
Publicado: (2021)

Proof-of-concept solution to create an interoperable timeline of healthcare data
por: Trivedi, Sapna, et al.
Publicado: (2023)

Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin
por: Raje, Sangeeta, et al.
Publicado: (2018)

Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a (14)C-microtracer and therapeutic dose in cancer patients
por: van Andel, L., et al.
Publicado: (2017)

Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study
por: Zwiers, Alexandra JM, et al.
Publicado: (2015)

An Investigation of the Metabolism and Excretion of KD101 and Its Interindividual Differences: A Microtracing Mass Balance Study in Humans
por: Kim, Anhye, et al.
Publicado: (2020)

Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients
por: Brill, MJE, et al.
Publicado: (2015)

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates
por: Brussee, Janneke M., et al.
Publicado: (2018)

Acute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study
por: Zwiers, Alexandra JM, et al.
Publicado: (2013)

Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis
por: Upadhyay, Parth J., et al.
Publicado: (2021)

Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero‐Test bile string
por: Tai, Guoying, et al.
Publicado: (2023)

Diagnosis and Treatment of Chronic Neuropathic and Mixed Pain in Children and Adolescents: Results of a Survey Study amongst Practitioners
por: de Leeuw, Thomas G., et al.
Publicado: (2020)

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization
por: Cheung, Kit Wun Kathy, et al.
Publicado: (2019)

A Phase 1, Open-Label Study in Healthy Subjects to Evaluate the Absolute Bioavailability of AG-221 by a Microtracer Approach
por: Wang, Xiaomin, et al.
Publicado: (2019)

Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial
por: de Leeuw, Thomas G., et al.
Publicado: (2019)

Correction to: Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial
por: de Leeuw, Thomas G., et al.
Publicado: (2019)

Quantifying the Pharmacodynamics of Morphine in the Treatment of Postoperative Pain in Preverbal Children
por: Goulooze, Sebastiaan C., et al.
Publicado: (2021)

Premedication With Midazolam Nasal Spray: An Alternative to Oral Midazolam in Children
por: Verma, Ravi K, et al.
Publicado: (2012)

A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption
por: Streekstra, Eva J., et al.
Publicado: (2022)

Representing Physician Suicide Claims as Nanopublications: Proof-of-Concept Study Creating Claim Networks
por: Leung, Tiffany I, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1gmm0s1qf3j1otpso4lvmk8nbi