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Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug‐Drug Interactions or in Special Populations: An Example Using Tofacitinib

Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It is eliminated via multiple pathways including oxidative metabolism (∼70%) and renal excretion (29%). This study aimed to predict the impact of drug‐drug interactio...

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Detalles Bibliográficos
Autores principales: Tse, Susanna, Dowty, Martin E., Menon, Sujatha, Gupta, Pankaj, Krishnaswami, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689764/
https://www.ncbi.nlm.nih.gov/pubmed/32592424
http://dx.doi.org/10.1002/jcph.1679