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First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant

A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early b...

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Detalles Bibliográficos
Autores principales: Wesemann, Friederike, Heutling, Anja, Wienecke, Paul, Kirschning, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689855/
https://www.ncbi.nlm.nih.gov/pubmed/32484951
http://dx.doi.org/10.1002/cbic.202000336