First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant

A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early b...

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Autores principales: Wesemann, Friederike, Heutling, Anja, Wienecke, Paul, Kirschning, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689855/
https://www.ncbi.nlm.nih.gov/pubmed/32484951
http://dx.doi.org/10.1002/cbic.202000336
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author Wesemann, Friederike
Heutling, Anja
Wienecke, Paul
Kirschning, Andreas
author_facet Wesemann, Friederike
Heutling, Anja
Wienecke, Paul
Kirschning, Andreas
author_sort Wesemann, Friederike
collection PubMed
description A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early building block as well as in the expression of two tailoring enzymes broadens the scope of chemo‐biosynthetic access to new maytansinoids. Remarkably, a ring‐expanded macrolactone derived from ansamitocin was created for the first time.
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spelling pubmed-76898552020-12-08 First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant Wesemann, Friederike Heutling, Anja Wienecke, Paul Kirschning, Andreas Chembiochem Communications A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early building block as well as in the expression of two tailoring enzymes broadens the scope of chemo‐biosynthetic access to new maytansinoids. Remarkably, a ring‐expanded macrolactone derived from ansamitocin was created for the first time. John Wiley and Sons Inc. 2020-07-02 2020-10-15 /pmc/articles/PMC7689855/ /pubmed/32484951 http://dx.doi.org/10.1002/cbic.202000336 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Wesemann, Friederike
Heutling, Anja
Wienecke, Paul
Kirschning, Andreas
First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
title First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
title_full First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
title_fullStr First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
title_full_unstemmed First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
title_short First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
title_sort first ring‐expanded maytansin lactone accessed by a new mutasynthetic variant
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689855/
https://www.ncbi.nlm.nih.gov/pubmed/32484951
http://dx.doi.org/10.1002/cbic.202000336
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