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‘Resistance is futile?’ – paradoxical inhibitory effects of K(ATP) channel closure in glucagon‐secreting α‐cells

By secreting insulin and glucagon, the β‐ and α‐cells of the pancreatic islets play a central role in the regulation of systemic metabolism. Both cells are equipped with ATP‐regulated potassium (K(ATP)) channels that are regulated by the intracellular ATP/ADP ratio. In β‐cells, K(ATP) channels are a...

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Detalles Bibliográficos
Autores principales:	Zhang, Quan, Dou, Haiqiang, Rorsman, Patrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Topical review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689873/ https://www.ncbi.nlm.nih.gov/pubmed/32716554 http://dx.doi.org/10.1113/JP279775

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