Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel Ca(V)3.1 caused by a mutation responsible for spinocerebellar ataxia

Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel Ca(V)3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountered a patient with the p.Arg1715His mutation, suffering from intractable resting tremor,...

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Detalles Bibliográficos
Autores principales: Hara, Naoyuki, Morino, Hiroyuki, Matsuda, Yukiko, Satoh, Kenichi, Hashimoto, Kouichi, Maruyama, Hirofumi, Kawakami, Hideshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690142/
https://www.ncbi.nlm.nih.gov/pubmed/33243296
http://dx.doi.org/10.1186/s13041-020-00700-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690142/
https://www.ncbi.nlm.nih.gov/pubmed/33243296
http://dx.doi.org/10.1186/s13041-020-00700-7

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