Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

Glioblastoma (GBM) is the most prevalent malignant primary brain tumor with a very poor survival rate. Temozolomide (TMZ) is the common chemotherapeutic agent used for GBM treatment. We recently demonstrated that simvastatin (Simva) increases TMZ-induced apoptosis via the inhibition of autophagic fl...

Descripción completa

Detalles Bibliográficos
Autores principales: Dastghaib, Sanaz, Shojaei, Shahla, Mostafavi-Pour, Zohreh, Sharma, Pawan, Patterson, John B., Samali, Afshin, Mokarram, Pooneh, Ghavami, Saeid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690447/
https://www.ncbi.nlm.nih.gov/pubmed/33105603
http://dx.doi.org/10.3390/cells9112339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690447/
https://www.ncbi.nlm.nih.gov/pubmed/33105603
http://dx.doi.org/10.3390/cells9112339

Ejemplares similares