Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase

Artemisinin (ART)-based combination therapies are recommended as first- and second-line treatments for Plasmodium falciparum malaria. Here, we investigated the impact of the RecQ inhibitor ML216 on the repair of ART-mediated damage in the genome of P. falciparum. PfBLM and PfWRN were identified as m...

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Detalles Bibliográficos
Autores principales: Suthram, Niranjan, Padhi, Siladitya, Jha, Payal, Bhattacharyya, Sunanda, Bulusu, Gopalakrishnan, Roy, Arijit, Bhattacharyya, Mrinal Kanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690958/
https://www.ncbi.nlm.nih.gov/pubmed/33239368
http://dx.doi.org/10.1128/mSphere.00956-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690958/
https://www.ncbi.nlm.nih.gov/pubmed/33239368
http://dx.doi.org/10.1128/mSphere.00956-20

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