UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution

The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein’s amino acids (‘intra-gene epistasis’). Our limited understanding of such epistasis hinders the correct pred...

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Detalles Bibliográficos
Autores principales: Zurek, Paul Jannis, Knyphausen, Philipp, Neufeld, Katharina, Pushpanath, Ahir, Hollfelder, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691348/
https://www.ncbi.nlm.nih.gov/pubmed/33243970
http://dx.doi.org/10.1038/s41467-020-19687-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691348/
https://www.ncbi.nlm.nih.gov/pubmed/33243970
http://dx.doi.org/10.1038/s41467-020-19687-9

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