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UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution
The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein’s amino acids (‘intra-gene epistasis’). Our limited understanding of such epistasis hinders the correct pred...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691348/ https://www.ncbi.nlm.nih.gov/pubmed/33243970 http://dx.doi.org/10.1038/s41467-020-19687-9 |