Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis

Progressive lung fibrosis is a major cause of mortality in systemic sclerosis (SSc) patients, but the underlying mechanisms remain unclear. We demonstrate that immune complexes (ICs) activate human monocytes to promote lung fibroblast migration partly via osteopontin (OPN) secretion, which is amplif...

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Detalles Bibliográficos
Autores principales: Gao, Xia, Jia, Guiquan, Guttman, Anna, DePianto, Daryle J., Morshead, Katrina B., Sun, Kai-Hui, Ramamoorthi, Nandhini, Vander Heiden, Jason A., Modrusan, Zora, Wolters, Paul J., Jahreis, Angelika, Arron, Joseph R., Khanna, Dinesh, Ramalingam, Thirumalai R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691442/
https://www.ncbi.nlm.nih.gov/pubmed/33294861
http://dx.doi.org/10.1016/j.xcrm.2020.100140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691442/
https://www.ncbi.nlm.nih.gov/pubmed/33294861
http://dx.doi.org/10.1016/j.xcrm.2020.100140

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