Cargando…

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

Mitochondrial respiration (oxidative phosphorylation, OXPHOS) is an emerging target in currently refractory cancers such as pancreatic ductal adenocarcinoma (PDAC). However, the variability of energetic metabolic adaptations between PDAC patients has not been assessed in functional investigations. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Masoud, Rawand, Reyes-Castellanos, Gabriela, Lac, Sophie, Garcia, Julie, Dou, Samir, Shintu, Laetitia, Abdel Hadi, Nadine, Gicquel, Tristan, El Kaoutari, Abdessamad, Diémé, Binta, Tranchida, Fabrice, Cormareche, Laurie, Borge, Laurence, Gayet, Odile, Pasquier, Eddy, Dusetti, Nelson, Iovanna, Juan, Carrier, Alice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691450/ https://www.ncbi.nlm.nih.gov/pubmed/33294863 http://dx.doi.org/10.1016/j.xcrm.2020.100143

Ejemplares similares

Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo
por: Reyes-Castellanos, Gabriela, et al.
Publicado: (2023)

Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance
por: Kaoutari, Abdessamad El, et al.
Publicado: (2021)

Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers
por: El Kaoutari, Abdessamad, et al.
Publicado: (2023)

Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition
por: Gajate, Consuelo, et al.
Publicado: (2021)

A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis
por: Mohamed Abd-El-Halim, Yousra, et al.
Publicado: (2021)

Metabolomic and Lipidomic Analysis of Serum Samples following Curcuma longa Extract Supplementation in High-Fructose and Saturated Fat Fed Rats
por: Tranchida, Fabrice, et al.
Publicado: (2015)

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity
por: Fraunhoffer, Nicolas Alejandro, et al.
Publicado: (2022)

Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
por: Tranchida, Fabrice, et al.
Publicado: (2017)

Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi)
por: Bian, Benjamin, et al.
Publicado: (2019)

Phosphorylation of OXPHOS Machinery Subunits: Functional Implications in Cell Biology and Disease
por: Castellanos, Ernesto, et al.
Publicado: (2019)

Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2022)

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments
por: Lan, Wenjun, et al.
Publicado: (2018)

Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer
por: Liu, Juan, et al.
Publicado: (2021)

Stromal cells promote chemoresistance of acute myeloid leukemia cells via activation of the IL-6/STAT3/OXPHOS axis
por: Hou, Diyu, et al.
Publicado: (2020)

Mitochondrial Metabolism in PDAC: From Better Knowledge to New Targeting Strategies
por: Reyes-Castellanos, Gabriela, et al.
Publicado: (2020)

Mitoribosomal regulation of OXPHOS biogenesis in plants
por: Janska, Hanna, et al.
Publicado: (2014)

Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases
por: Kawamata, Hibiki, et al.
Publicado: (2017)

Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models
por: Hoare, Owen, et al.
Publicado: (2021)

Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome
por: Juiz, Natalia Anahi, et al.
Publicado: (2019)

Impaired OXPHOS Complex III in Breast Cancer
por: Owens, Kjerstin M., et al.
Publicado: (2011)

Correction: Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases
por: Kawamata, Hibiki, et al.
Publicado: (2018)

The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation
por: Loncle, C, et al.
Publicado: (2016)

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine
por: Lomberk, Gwen, et al.
Publicado: (2019)

Selection of Intracellular Single-Domain Antibodies Targeting the HIV-1 Vpr Protein by Cytoplasmic Yeast Two-Hybrid System
por: Matz, Julie, et al.
Publicado: (2014)

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
por: Santofimia-Castaño, Patricia, et al.
Publicado: (2018)

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes
por: van der Sluis, Eli O., et al.
Publicado: (2015)

Human diseases associated with defects in assembly of OXPHOS complexes
por: Ghezzi, Daniele, et al.
Publicado: (2018)

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia
por: Nelson, Margaret AM, et al.
Publicado: (2021)

Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers
por: Chen, Chia-Lin, et al.
Publicado: (2021)

Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction
por: Adant, Isabelle, et al.
Publicado: (2022)

Fecal Metabolic Profiling of Breast Cancer Patients during Neoadjuvant Chemotherapy Reveals Potential Biomarkers
por: Zidi, Oumaima, et al.
Publicado: (2021)

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma
por: Molejon, Maria Inés, et al.
Publicado: (2015)

Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells
por: Invernizzi, F., et al.
Publicado: (2012)

The molecular evolutionary dynamics of oxidative phosphorylation (OXPHOS) genes in Hymenoptera
por: Li, Yiyuan, et al.
Publicado: (2017)

Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
por: Krahn, Daniel, et al.
Publicado: (2020)

OXPHOS Organization and Activity in Mitochondria of Plants with Different Life Strategies
por: Ukolova, Irina V., et al.
Publicado: (2023)

Limitation and challenges in using pancreatic cancer‐derived organoids as a preclinical tool
por: Fraunhoffer, Nicolas A., et al.
Publicado: (2022)

Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma
por: Molejon, María Inés, et al.
Publicado: (2018)

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity
por: Giessner, Caroline, et al.
Publicado: (2018)

The Fhit protein: an opportunity to overcome chemoresistance
por: Gaudio, Eugenio, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qmkr711gsuiq6stbbbb23ibnsk