Enhancing the Oral Bioavailability of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers: In Vitro Characterization and Absorption in Rats after Oral Administration

Candesartan Cilexetil (CC) is a prodrug widely used in the treatment of hypertension and heart failure, but it has some limitations, such as very poor aqueous solubility, high affinity to P-glycoprotein efflux mechanism, and hepatic first-pass metabolism. Therefore, it has very low oral bioavailabil...

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Detalles Bibliográficos
Autores principales: Anwar, Walid, Dawaba, Hamdy M., Afouna, Mohsen I., Samy, Ahmed M., Rashed, Mohammed H., Abdelaziz, Abdelaziz E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692391/
https://www.ncbi.nlm.nih.gov/pubmed/33142816
http://dx.doi.org/10.3390/pharmaceutics12111047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692391/
https://www.ncbi.nlm.nih.gov/pubmed/33142816
http://dx.doi.org/10.3390/pharmaceutics12111047

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