An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica

Fasciola hepatica is a global parasite of humans and their livestock. Regulation of parasite-secreted cathepsin L-like cysteine proteases associated with virulence is important to fine-tune parasite-host interaction. We uncovered a family of seven Kunitz-type (FhKT) inhibitors dispersed into five ph...

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Detalles Bibliográficos
Autores principales: Smith, David, Cwiklinski, Krystyna, Jewhurst, Heather, Tikhonova, Irina G., Dalton, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692546/
https://www.ncbi.nlm.nih.gov/pubmed/33244035
http://dx.doi.org/10.1038/s41598-020-77687-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692546/
https://www.ncbi.nlm.nih.gov/pubmed/33244035
http://dx.doi.org/10.1038/s41598-020-77687-7

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