Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in MSH2+/- Carriers

Lynch syndrome (LS) is an inherited predisposition to early onset of various cancers, caused by mutation in a DNA mismatch repair (MMR) gene. In heterozygous MMR(+/−) carriers, somatic mutation, loss or silencing of the wild type allele increases the mutation rate, facilitating the initiation of MMR...

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Detalles Bibliográficos
Autores principales: Garrido-Navas, M. Carmen, Tippins, Frances, Barwell, Julian, Hoffman, Jonathan, Codd, Veryan, Royle, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692680/
https://www.ncbi.nlm.nih.gov/pubmed/33142697
http://dx.doi.org/10.3390/life10110265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692680/
https://www.ncbi.nlm.nih.gov/pubmed/33142697
http://dx.doi.org/10.3390/life10110265

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