An Acid‐Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities

A rationally designed pH‐activatable fluorescent probe (pHocas‐RIS) has been used to measure localised pH levels in osteocytic lacunae in bone tissue. Conjugation of the moderate bone‐binding drug risedronate to a pH‐activatable BODIPY fluorophore enables the probe to penetrate osteocytic lacunae ca...

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Detalles Bibliográficos
Autores principales: Hashimoto, Ryu, Minoshima, Masafumi, Kikuta, Junichi, Yari, Shinya, Bull, Steven D., Ishii, Masaru, Kikuchi, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692916/
https://www.ncbi.nlm.nih.gov/pubmed/32744428
http://dx.doi.org/10.1002/anie.202006388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692916/
https://www.ncbi.nlm.nih.gov/pubmed/32744428
http://dx.doi.org/10.1002/anie.202006388

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