Switching the Switch: Ligand Induced Disulfide Formation in HDAC8

Human histone deacetylase 8 is a well‐recognized target for T‐cell lymphoma and particularly childhood neuroblastoma. PD‐404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanat...

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Detalles Bibliográficos
Autores principales: Jänsch, Niklas, Sugiarto, Wisely Oki, Muth, Marius, Kopranovic, Aleksandra, Desczyk, Charlotte, Ballweg, Matthias, Kirschhöfer, Frank, Brenner‐Weiss, Gerald, Meyer‐Almes, Franz‐Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692948/
https://www.ncbi.nlm.nih.gov/pubmed/32428298
http://dx.doi.org/10.1002/chem.202001712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692948/
https://www.ncbi.nlm.nih.gov/pubmed/32428298
http://dx.doi.org/10.1002/chem.202001712

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