Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin

Binders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed...

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Detalles Bibliográficos
Autores principales: Bachem, Gunnar, Wamhoff, Eike‐Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix, Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693190/
https://www.ncbi.nlm.nih.gov/pubmed/32749019
http://dx.doi.org/10.1002/anie.202006880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693190/
https://www.ncbi.nlm.nih.gov/pubmed/32749019
http://dx.doi.org/10.1002/anie.202006880

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